​

• Giri, D.; Raja, K.; Mugesh, G.* A Simple Substitution on Thyroid Hormones Remarkably Alters the Regioselectivity of Deiodination by a Deiodinase Mimic.

       Chem. Eur. J. 2022, 28, 0000-0000. Read more....​

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• Singh, S.; Ghosh, S.; Pal, V. K.; Munshi, M. H.; Shekhar, P.; Murthy, T. R. N.; Mugesh, G.*;  Singh, A.* Antioxidant nanozyme counteracts HIV-1 by modulating intracellular redox potential.

       EMBO Mol. Med. 2021, 13, e13314. Read more....​

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• Singh, N.; NaveenKumar, S. K.; Geethika, M.; Mugesh, G.* Cerium vanadate nanozyme with specific superoxide dismutase activity regulates mitochondrial function and ATP synthesis in neuronal cells.

       Angew. Chem. Int. Ed. 2021, 60, 3121 - 3130. Read more....​

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• Chakrabarty, G.; NaveenKumar, S. K.; Kumar, S.; Mugesh, G.* Modulation of Redox Signalling and Thiol Homeostasis in Red Blood Cells by Peroxiredoxin Mimetics.

       ACS Chem. Biol. 2020, 15, 2673 – 2682. Read more....

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• Khulbe, K.; Karmakar, K.; Ghosh, S.; Chandra, K.; Chakravortty, D.*, Mugesh, G.* Nanoceria-Based Phospholipase-Mimetic Cell Membrane Disruptive Anti-Biofilm Agents.

       ACS Appl. Bio Mater. 2020, 3, 4316 – 4328. Read more....

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• Mondal, S.; Manna, D.; Raja, K.; Mugesh, G.* Halogen Bonding in Biomimetic Deiodination of Thyroid Hormones, their Metabolites and Halogenated Nucleosides.

       ChemBioChem, 2020, 21, 911 - 923. Read more....

       [This article has been highlighted on the Cover Page of the Journal]

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• Arai, K.; Matsunaga, T.; Ueno, H.; Akahoshi, N.; Sato, Y.; Chakrabarty, G.; Mugesh, G.*; Iwaoka, M.* Modeling Thioredoxin Reductase-like Activity Using Cyclic Selenenyl Sulfides: Participation of an NH...Se Hydrogen Bond through Stabilization of the Mixed Se–S Intermediate.

       Chem. Eur. J. 2019, 25, 12751-12760. Read more....

       [This article has been highlighted on the Cover Page of the Journal]

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• Govindaraj, V.; Ungati, H.; Jakka, S. R.; Bose, S.; Mugesh, G.* Directing Traffic: Halogen Bond-mediated Membrane Transport.

       Chem. Eur. J., 2019, 25, 11180 - 11192. Read more....​

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• Ungati, H.; Govindaraj, V.; Narayanan, M.; Mugesh, G.* Probing the formation of a Seleninic Acid in Living Cells by a Fluorescence Switching of a Glutathione Peroxidase Mimetic.

       Angew. Chem. Int. Ed. 2019, 58, 8156 - 8160. Read More....​

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• Ghosh, S.; Roy, P.; Prasad, S.; Mugesh, G.* Crystal-Facet-Dependent Denitrosylation: Modulation of NO Release from S-nitrosothiols by Cu2O Polymorphs.

       Chem. Sci. 2019, 10, 5308 - 5318. Read more....

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• Reddy, K. M.; Mugesh, G.* Modelling the Inhibition of Selenoproteins by Small Molecules using Cysteine and Selenocysteine Derivatives.

       Chem. Eur. J., 2019, 25, 8875 - 8883. Read more....

       [This article has been selected as Hot Paper].

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• Singh, N.; Mugesh, G.* CeVO4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species.

       Angew. Chem. Int. Ed. 2019, 58, 7797 - 7801. Read More....

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• Jakka, S.R.; Govindaraj, V.; Mugesh, G.* A Single Atom Change Facilitates the Membrane Transport of Green Fluorescent Proteins in Mammalian Cells.

       Angew. Chem. Int. Ed. 2019, 58, 7713 - 7717. Read More....

       [This article has been selected as Hot Paper].

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• Singh, N.; Savanur, M. A.; Srivastava, S.; D'Silva, P.*; Mugesh, G.* A manganese oxide nanozyme prevents oxidative damage of biomolecules without affecting the endogenous antioxidant system.

       Nanoscale, 2019, 11, 3855 - 3863. Read more....​

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• Ungati, H.; Govindaraj, V.; Nair, C. R.; Mugesh, G.* Halogen-mediated Membrane Transport – An Efficient Strategy for the Enhancement of Cellular Uptake of Synthetic Molecules.

       Chem. Eur. J., 2019, 25, 3391 – 3399. Read more....

       [This article is denoted as Very Important Paper (VIP)].

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• Mondal, S.; Mugesh, G.* Dehalogenation of Halogenated Nucleobases and Nucleosides by Organoselenium Compounds.

       Chem. Eur. J., 2019, 24, 1773 – 1780. Read more....

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• Khulbe, K.; Roy, P.; Radhakrishnan, A.; Mugesh, G.* An Unusual Two-step Hydrolysis of Nerve Agents by a Nanozyme.

       ChemCatChem, 2018, 10, 4826 - 4831. Read more....

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• NaveenKumar, S. K.; Sharathbabu, B. N.; Hemshekhar, M.; Kemparaju, K.*; Girish, K. S.*; Mugesh, G.* The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets.

       ACS Chem. Biol. 2018, 13, 1996 – 2002. Read more....

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• Ungati, H.; Govindaraj, V.; Mugesh, G.*  The Remarkable Effect of Halogen Substitution on the Membrane Transport of Fluorescent Molecules in Living Cells.

       Angew. Chem. Int. Ed., 2018, 57, 8989 - 8993. Read more....

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• Singh, N.; Geethika, M.; Eswarappa, S. M.; Mugesh, G.* Manganese-based Nanozymes: Multienzyme Redox Activity and Effect on the Nitric Oxide Produced by Endothelial Nitric Oxide Synthase.

       Chem. Eur. J., 2018, 24, 8393 – 8403. Read more....

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• Ghosh, S.; Roy, P.; Karmodak, N.; Jemmis, E. D.; Mugesh, G.*  Nanoisozymes: Crystal Facet-Dependent Enzyme Mimetic Activity of V2O5 Nanomaterials.

       Angew. Chem. Int. Ed., 2018, 57, 4510 - 4515. Read more....

       [This article has been highlighted on the Cover Page of the Journal]

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• Singh, N.; Savanur, M. A.; Srivastava, S.; D'Silva, P.*; Mugesh, G.* Redox Modulatory Mn3O4 Nanozyme with Multi-enzyme Activity Provides Efficient Cytoprotection to Human Cells in Parkinson's Disease Model.

       Angew. Chem. Int. Ed., 2017, 56, 14267 – 14271. Read more....

       [This article has been selected as Hot Paper by the Editors]

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• Mondal, S.; Raja, K.; Schweizer, U.; Mugesh, G.* Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones. (Invited Review).

       Angew. Chem. Int. Ed., 2016, 55, 7606 – 7630. Read more....

       [This review has been highlighted on the Cover Page of the Journal]

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• Vernekar, A. A.; Das, T.; Mugesh, G.* Vacancy-Engineered Nanoceria: Enzyme Mimetic Hotspots for the Degradation of Nerve Agents.

       Angew. Chem. Int. Ed., 2016, 55, 1412 - 1416. Read more....

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• Vernekar, A.A.; Das, T.; Ghosh, S.; Mugesh, G.* Remarkably Efficient MnFe2O4-based Oxidase Nanozyme.

       Chem. Asian. J., 2016, 11, 72 – 76. Read more....

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• Mondal, S.; Mugesh, G.* Structure Elucidation and Characterization of Different Thyroxine Polymorphs.

       Angew. Chem. Int. Ed., 2015, 54, 10833 - 10837. Read more....

       [Highlighted in the Spotlights Section of Chemistry – A European Journal]

       [A highlight by U. Schweizer and C. Steegborn in Angewandte Chemie. Click here to read the Highlight]

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• Mondal, S.; Manna, D.; Mugesh, G.* Selenium-mediated Dehalogenation of Halogenated Nucleosides and its Relevance to the DNA Repair Pathway.

       Angew. Chem. Int. Ed., 2015, 54, 9298 - 9302. Read more....

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• Bhowmick, D.; Srivastava, S.; D'Silva, P.*; Mugesh, G.* Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage.

       Angew. Chem. Int. Ed., 2015, 54, 8449 - 8453. Read more....
       [This article is denoted as Very Important Paper (VIP)].

       [A highlight by Thomas Wirth appeared in Angewandte Chemie. Click here to read the Highlight]

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• Raja, K.; Mugesh, G.* Remarkable Effect of Chalcogen Substitution on an Enzyme Mimetic for Deiodination of Thyroid Hormones.

       Angew. Chem. Int. Ed., 2015, 54, 7674 - 7678. Read more....

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• Thomas, S. P.; Satheeshkumar, K.; Mugesh, G.*; Guru Row, T.N.* Unusually Short Chalcogen Bonds Involving 'Organic Selenium': Insights into the Se-N Bond Cleavage Mechanism of Antioxidant Ebselen and Analogues. 
  Chem. Eur. J., 2015, 21, 6793 – 6800. Read more....

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• Manna, D.; Mondal, S.; Mugesh, G.* Halogen Bonding Controls the Regioselectivity of the Deiodination of Thyroid Hormones and their Sulfate Analogues. 

       Chem. Eur. J., 2015, 21, 2409 – 2416. Read more....

       [This article has been selected as Hot Paper by the Editors of the Journal].

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• Vernekar, A. A.; Sinha, D.; Srivastava, S.; Paramasivam, P. U.; D'Silva, P.*; Mugesh, G.*

       An Antioxidant Nanozyme that Uncovers the Cytoprotective Potential of Vanadia Nanowires.
       Nature Commun. 2014, 5, 5301. Read more....

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• Mondal, S.; Mugesh, G.* Regioselective Deiodination of Iodothyronamines, Endogenous Thyroid Hormone Derivatives, by Deiodinase Mimics. 

       Chem. Eur. J., 2014, 20, 11120 – 11128. Read more....

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• Manna, D.; Roy, G.; Mugesh, G.* Antithyroid Drugs and their Analogues: Synthesis, Structure and Mechanism of Action.

       Acc. Chem. Res., 2013, 11, 2706 - 2715. Read more....

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• Vernekar, A. A.; Mugesh, G.* Catalytic Reduction of Graphene Oxide Nanosheets by Glutathione Peroxidase Mimetics reveals a New Structural Motif in Graphene Oxide.

       Chem. Eur. J., 2013, 19, 16699 - 16706.
       [Highlighted in the "Hot Topics" section of Wiley-VCH].

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• Vernekar, A. A.; Mugesh, G.* Hemin-Functionalized Reduced Graphene Oxide Nanosheets Reveal Peroxynitrite Reduction and Isomerization Activity.

       Chem. Eur. J., 2012, 18, 15122 - 15132.

       [Highlighted in the "Hot Topics" section of Wiley-VCH].

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• Manna, D.; Mugesh, G.* Regioselective Deiodination of Thyroxine by Iodothyronine Deiodinase Mimics: An Unusual Mechanistic Pathway Involving Cooperative Chalcogen and Halogen Bonding.

       J. Am. Chem. Soc., 2012, 134, 4269 - 4279. Read more....
       [This work has been highlighted as News & Views in Nature Chemistry].

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• Manna, D.; Mugesh, G.* Deiodination of Thyroid Hormones by Iodothyronine Deiodinase Mimics: Does  an   Increase in the Reactivity Alter the Regioselectivity?

       J. Am. Chem. Soc., 2011, 133, 9980 - 9983. Read more....​

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• Manna, D.; Mugesh, G.* A Chemical Model for the Inner-Ring Deiodination of Thyroxine by Iodothyronine Deiodinase.

       Angew. Chem. Int. Ed., 2010, 49, 9246 - 9249. Read more....

 

• Bhabak, K. P.; Mugesh, G.* Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants.

       Acc. Chem. Res., 2010, 43, 1408 - 1419. Read more....

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• Sarma, B. K.; Manna, D.; Minoura, M.; Mugesh, G.* Synthesis, Structure, Spirocyclization Mechanism and Glutathione Peroxidase-like Antioxidant Activity of Stable Spirodiazaselenurane and Spirodiazatellurane.

       J. Am. Chem. Soc., 2010, 132, 5364 - 5374. Read more....

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• Sarma, B. K.; Mugesh, G.* Redox Regulation of Protein Tyrosine Phosphatase 1B (PTP1B): A Biomimetic Study on the Unexpected Formation of a Sulfenyl Amide Intermediate.

       J. Am. Chem. Soc., 2007, 129, 8872 - 8881. Read more....

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• Roy, G.; Mugesh, G.* Anti-Thyroid Drugs and Thyroid Hormone Synthesis: Effect of Methimazole Derivatives on Peroxidase-Catalyzed Reactions.

       J. Am. Chem. Soc., 2005, 127, 15207 - 15217. Read more....

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• Sarma, B. K.; Mugesh, G.* Glutathione Peroxidase (GPx)-like Antioxidant Activity of the Organoselenium Drug Ebselen: Unexpected Complications with Thiol Exchange Reactions.

       J. Am. Chem. Soc., 2005, 127, 11477 - 11485. Read more....

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• Wismach, C.; du Mont, W.-W.; Jones, P. G.; Ernst, L.; Papke, U.; Mugesh, G.; Kaim, W.; Wanner, M.; Becker, K. D. Selenol Nitrosation and Se-Nitrososelenol-Homolysis: a Reaction Path with Possible Biochemical Implications.

       Angew. Chem. Int. Ed. 2004, 43, 3970 - 3974. Read more....

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• Roy, G.; Nethaji, M.; Mugesh, G.* Biomimetic Studies on Anti-thyroid Drugs and Thyroid Hormone Synthesis.

       J. Am. Chem. Soc. 2004, 126, 2712 - 2713. Read more....

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Click here to see the complete list of publications.