The research activities in our laboratory involve organic/inorganic chemical synthesis, artificial enzymes including nanozymes, genetic code expansion and other multidisciplinary studies in the area of biomedical research. Our recent efforts are directed toward understanding the redox regulation by synthetic compounds in mammalian cells, thyroid hormone metabolism and thyroid related disorders, development of molecular probes for the detection and quantification of reactive oxygen species in the cells and oxidative stress biomarkers. We have a unique multidisciplinary team for an efficient collaboration within the laboratory and outside to undertake challenging contemporary research problems at the chemistry-biology interface.
A Redox Modulatory SOD Mimetic Nanozyme Prevents the Formation of Cytotoxic Peroxynitrite and Improves Nitric Oxide Bioavailability in Human Endothelial Cells.
The SOD mimetic CeVO4 nanozymes effectively regulate the bioavailability of both NO and superoxide, the two key constitutive molecules of vascular endothelium, even in the absence of the cellular SOD enzyme.
Adv. Healthcare Mater. 2023, 12, 202300621.
Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next-Generation Therapeutics.
The advances in the development of redox-active nanozymes and their biomedical applications are described. We highlight the therapeutic significance of the antioxidant and prooxidant nanozymes in various diseases such as cancer, neurodegeneration, and cardiovascular diseases.
Angew. Chem. Int. Ed. 2023, 62, e202301232.
A Simple Substitution on Thyroid Hormones Remarkably Alters the Regioselectivity of Deiodination by a Deiodinase Mimic.
The modulation of the electronic properties of the iodine atoms in thyroxine (T4) through the phenolic group has a remarkable influence on the regioselectivity of the deiodination.
Chem. Eur. J. 2023, 29, e202203111.
Cerium vanadate nanozyme with specific superoxide dismutase activity regulates mitochondrial function and ATP synthesis in neuronal cells.
The first example of a nanozyme that can fully substitute the function of SOD1 and SOD2 in neuronal cells and regulate the synthesis of ATP under oxidative stress conditions is described.
Angew. Chem. Int. Ed. 2021, 60, 3121.
Modulation of Redox Signalling and Thiol Homeostasis in Red Blood Cells by Peroxiredoxin Mimetics.
The first examples of selenium compounds that can prevent the oxidative stress-induced eryptosis by exhibiting an unusual Prx2-like redox activity under conditions when the cellular Prx2 and CAT enzymes are inhibited.