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Mugesh Research Group

Inorganic & Physical Chemistry

Indian Institute of Science

​Bangalore 560012

​Tel: +91-80-2360 2566/2293 3354    

Fax: +91-80-2360 2566



The research activities on our laboratory involve multi-step organic/ inorganic chemical synthesis, development of artificial enzymes, including nanozymes, that can combat oxidative stress, maintain the reactive oxygen species (ROS) homeostasis and regulate the redox processes in cellular signaling under disease conditions. Our research is focused on understanding of the molecular mechanism and complex chemical pathways of thyroid hormone metabolism and the development of novel methods for improving the membrane transport of small molecules, peptides and proteins.

       More details about our research....

October 14, 2020

Cerium vanadate nanozyme with specific superoxide dismutase activity regulates mitochondrial function and ATP synthesis in neuronal cells.
Angew. Chem. Int. Ed. 2020

September 10, 2020

Modulation of Redox Signalling and Thiol Homeostasis in Red Blood Cells by Peroxiredoxin Mimetics.
ACS Chem. Biol. 2020

May 21, 2020

Nanoceria-Based Phospholipase-Mimetic Cell Membrane Disruptive Anti-Biofilm Agents.
ACS Appl. Bio Mater. 2020

November 05, 2019

Halogen Bonding in Biomimetic Deiodination of Thyroid Hormones, their Metabolites and Halogenated Nucleosides.
ChemBioChem, 2019

June 10, 2019

Directing Traffic: Halogen bond-mediated Membrane Transport.
Chem. Eur. J. 2019

April 23, 2019

Probing the formation of a Seleninic Acid in Living Cells by a Fluorescence Switching of a Glutathione Peroxidase Mimetic.
Angew. Chem. Int. Ed. 2019

April 23, 2019

Crystal-Facet-Dependent Denitrosylation: Modulation of NO Release from S-nitrosothiols by Cu2O Polymorphs.
Chem. Sci. 2019

April 15, 2019

Modelling the Inhibition of Selenoproteins by Small Molecules using Cysteine and Selenocysteine Derivatives.
Chem. Eur. J. 2019.

April 14, 2019

A Single Atom Change Facilitates the Membrane Transport of Green Fluorescent Proteins in Mammalian Cells.
Angew. Chem. Int. Ed. 2019.

April 04, 2019

CeVO4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species.
Angew. Chem. Int. Ed. 2019.

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Number of visitors since June 2015

August 18, 2020

G. Mugesh has been awarded the J. C. Bose National Fellowship for a Second Term (2021-25)

June 22, 2020

Our work on nanozyme-based antibacterial agents has been highlighted in Deccan Herald and The Times of India

March 31, 2020

Namrata Singh has been awarded the IUPAC-SOLVAY International Award for Young Chemists. 

November 7, 2019

Mugesh has been selected for the Infosys Prize in Physical Sciences for the year 2019. 

September 17, 2019

Namrata Singh has been awarded the IIT Bombay Metrohm Young Chemist Award 2019 for "Innovation in Research". 

May 8, 2019

Our new paper on halogen-mediated membrane transport of green fluorescent proteins has been selected as a "Hot Paper" in Angewandte Chemie.

April 20, 2019

Our work on the direct delivery of proteins into mammalian cells using a halogen bonding strategy is highlighted in "The Hindu" newspaper.

February 15, 2019

Namrata Singh has been awarded an ACS poster prize at the NSC-24 at CLRI, Chennai.

December 8, 2018

Punarbasu Roy has been awarded a poster prize at the I-DEC-2018 at IISER Bhopal.

August 30, 2018

G. Mugesh featured in an "Author Profile" in Angewandte Chemie.

July 30, 2018

Our work on halogen bonding in the cellular uptake of fluorescent probes is highlighted in "The Hindu" newspaper.

May 27, 2018

Our work on the application of V2O5 nanozyme in cellular redox regulation is highlighted in "The Hindu" newspaper.

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