



Research Activities
The research activities in our laboratory involve organic/inorganic chemical synthesis, artificial enzymes including nanozymes, genetic code expansion and other multidisciplinary studies in the area of biomedical research. Our recent efforts are directed toward understanding the redox regulation by synthetic compounds in mammalian cells, thyroid hormone metabolism and thyroid related disorders, development of molecular probes for the detection and quantification of reactive oxygen species in the cells and oxidative stress biomarkers. We have a unique multidisciplinary team for an efficient collaboration within the laboratory and outside to undertake challenging contemporary research problems at the chemistry-biology interface.
Recent Publications
Small molecule selenium-based Glutathione Peroxidase 4 mimetic inhibits lipid peroxidation and protects cultured neurons from ferroptosis.
2025-06-24
The development of GPX4 functional mimetics represents a promising strategy to prevent ferroptosis and its associated pathologies. In this paper, the translational potential of GPX4 functional mimetic for targeting ferroptosis-driven neurodegenerative disorders is discussed.
Free Radic. Biol. Med. 2025, 240, 000-000
Chalcogen Bonding Boosts the Uptake of Small Molecules in Mammalian Cells.
2025-06-17
Chalcogen bonding (ChB) and its directionality can be used as a driving force to improve the cellular uptake of small molecules. The uptake of selenium and tellurium compounds was found to be remarkably higher than that of their oxygen and sulfur analogues.